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. Author manuscript; available in PMC: 2013 Mar 28.
Published in final edited form as: Cell. 2012 Sep 28;151(1):153–166. doi: 10.1016/j.cell.2012.06.053

Figure 7.

Figure 7

Potential modes of utilization of preformed enhancer network by Foxp3 during Treg cell differentiation. (A) The majority of Foxp3 binding sites are found within enhancers that are occupied by Foxp3 cofactors before Foxp3 is expressed and are accessible in precursor cells. (B) Foxp3 binds to sites occupied by a related forkhead transcription family member Foxo1, which serves as a “placeholder” and can be displaced by Foxp3. (C) Foxp3 is recruited to enhancers primed in a TCR signaling dependent manner during Treg cell differentiation likely via NFAT-AP1 assisted chromatin remodeling.