Table 1.
Comparison of immunogenicity of formalin-inactivated RG and wild-type (wt) viruses
| Antigen |
Log2 (titer of neutralizing antibody) against (mean (SD)): |
||||||
|---|---|---|---|---|---|---|---|
| EV71-B2 | EV71-B4 | EV71-B5 | EV71-C1 | EV71-C2 | EV71-C4 | EV71-C5 | |
| B5-wt |
7(0.89) |
7.8(0.98) |
8(0.89) |
5.1(0.75) |
5.7(0.75) |
4.2(0.75) |
4.7(0.82) |
| B5-RG1 |
7(1.26) |
7.3(1.03) |
7.8(0.75) |
4.8(0.75) |
5(0.63) |
4.3(0.82) |
4.83(0.75) |
| B5-RG2 |
7(0.89) |
7.16(1.17) |
8 (0.63) |
4.6(0.82) |
5.2 (0.4) |
4.2(0.98) |
4.5(0.55) |
| PBS | < 3 | < 3 | < 3 | < 3 | < 3 | < 3 | < 3 |
Cross-neutralization antibodies titers elicited in mice by RG and wt EV71-B5 viruses were almost the same against homologous or heterologous EV71 strains from different subgenogroups. The experiment was duplicated and the data represents the arithmetic mean value (n=6)±SD.