Table 2.

Amino acid variations in the HCV NS3 protein associated with resistance mutations to HCV NS3 protease inhibitors, compensatory and enhanced replication

NS3 Protease positiona	HCV variation in different genotypes (number of sequenced patients)b
	1a	1b	2	3	4
	(n = 31)	(n = 39)	(n = 30)	(n = 33)	(n = 23)
36 (R)	V36Lc(2)e	V36	L36	L36	L36
41 (R)	Q41	Q41	Q41	Q41	Q41
43 (R)	F43	F43	F43	F43	F43
54 (R)	T54S (2)e	T54	T54	T54	T54
55 (R)	V55A/I (2)e	V55F (1)e	V55	V55	V55
79 (R)	D79	D79	E79	D79	D79
80 (R)	Q80K/L (3)e	Q80L/N (2)e	G80	Q80	Q80
109 (R)	R109	R109	R109	R109	R109
138 (R)	S138	S138C (1)d	S138	S138	S138
155 (R)	R155	R155	R155	R155	R155
156 (R)	A156	A156	A156	A156	A156
158 (R)	V158	V158	V158M (1)e	V158	V158
168 (R)	D168	D168	D168	D168Q (33)e	D168E (3)e
170 (R)	I170	V170I (12)d	I170	I170V (1)d	V170
175 (R)	L175	M175L (1)e	L175	L175	L175
176 (R)	E176	E176	D176	S176N (4)d	E176
71 (C)	V71	I71V/L (5)e	V71	A71S (1)d	V71
72 (C)	I72T/F (2)e	T72I/A/L (11)e	T72	L72F (1)d	N72C (2)d
86 (C)	P86	Q86P (6)e	P86S (1)d	P86S (2)d	P86
88 (C)	P88	P88	P88	P88	P88

^aR, position associated with primary resistance; C, position associated with compensatory mutations; (Lopez, 2008; Flint, 2009; Susser, 2009; Lentz, 2010; Verbimen, 2010; Romano, 2010, Halfon, 2011).

^bReference strains for each genotype: M62321 (1a), D90208 (1b), D50409 (2c), D17763 (3a), and Y11604 (4a).

^cLetter on the left represents the wild type amino acid, on the right, the amino acid substitution. The number of patients with mutant HCV strains is indicated in brackets.

^dPolymorphism with no associated resistance.

^e Amino acid changes conferring resistance are reported in bold.