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. 2012 Nov 1;13(13):1235–1243. doi: 10.4161/cbt.21813

Table 2. Univariate and multivariate analysis of OS rate (log-rank test).

Univariate analysis
 
 
 
Clinical parameter n Median OS (months) p value
Age
 
 
 
< 75 y
231
58.9
0.0472
≥ 75 y
38
36.7
 
Gender
 
 
 
Male
92
42.6
0.0328
Female
181
62.7
 
Primary tumor localization
 
 
 
Sigmoid colon
100
68
0.0039
Colon/Rectum
173
43.5
 
WHO performance status
 
 
 
0–1
258
58.4
0.0027
2–3
15
19
 
Karnofsky performance status
≤ 80
16
19.4
0.0036
> 80
257
58.1
 
Lymph node involvement grade
 
 
 
Involved lymph nodes
60
65.3
0.0031
Uninvolved lymph nodes
231
46.3
 
Pretreatment CEA level (ng/ml)
 
 
 
≤ 5
170
25.6
< 0.0001
> 5 89 76.3  
Multivariate analysis
 
 
 
Clinical parameter HR (95% CI) p value  
  Primary tumor localization
 
 
 
Sigmoid colon vs. Rectum/Colon
0.53 (0.35–0.81)
0.0032
 
Lymph node involvement grade
 
 
 
Involved vs. Uninvolved
1.94 (1.17–3.24)
0.0107
 
WHO performance status
 
 
 
0–1 vs. 2
0.34 (0.18–0.64)
0.0008
 
Karnofsky performance status
 
 
 
≤ 80 vs. > 80
NS
> 0.05
 
Pretreatment CEA level (ng/ml)
 
 
 
≤ 5 vs. > 5
2.68 (2.09–3.44)
< 0.0001
 
Age
 
 
 
≤ 75 vs. > 75 y
NS
> 0.05
 
Gender
 
 
 
Male vs. female NS > 0.05  

NS, not significant.