Figure 7. Schematics of connectivity among select VSP green-yellow and blue module genes in both regions.

(A) Network connections are depicted between gene markers of oligodendrocytes in the VSP green-yellow module. Thicker/darker lines between nodes denote stronger connections. Node and label size represent overall connectivity among this group of genes (larger = more connected), nodes are colored by module assignment, and each gene symbol is appended (after underscore) by the rank of its kME value in the module, e.g. PLP1 has the 7^th highest kME in the green-yellow module, MBP has the 22^nd highest kME, etc. Connections <0.1 are not shown. Area X connectivity between the same genes is shown in (B), where node and label size indicate connectivity among this group of genes in area X, and nodes are colored by area X module assignment. Visual inspection suggests that VSP connectivity patterns were not well-preserved in area X. Note that 6/8 genes were not in any area X module and were thus assigned the color “grey”. (C–D) Analogous plots depicting VSP and area X connections between genes associated with Parkinson's Disease in the VSP blue module: VSP (C), area X (D).