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. 2012 Nov 8;7(11):e49030. doi: 10.1371/journal.pone.0049030

Figure 1. Effect of supplementation with powdered persimmon leaf on the glucose regulation in C57BL/KsJ-db/db mice.

Figure 1

A; fasting blood glucose level. B&C plasma insulin level and HOMA-IR. D&E activity and/or mRNA expression of enzymes for hepatic gluconeogenesis and glucose utilization. The mRNA levels were analyzed by Northern blot analysis using GK probes and normalized to an internal control (GAPDH). Three independent analyses were performed. F; hepatic glycogen content. Values are the mean ± S.E., n = 10. *p<0.05, **p<0.01, ***p<0.001. GAPDH; glyceraldehyde-3-phosphate dehydrogenase, G6Pase; glucose-6-phosphatase, GK; glucokinase, HOMA-IR; homeostatic index of insulin resistance, PEPCK; phosphoenolpyruvate carboxykinase, PL; powdered persimmon leaf.