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. 2012 Nov 8;7(11):e49030. doi: 10.1371/journal.pone.0049030

Figure 2. Effect of supplementation with powdered persimmon leaf on the lipid regulation in C57BL/KsJ-db/db mice.

Figure 2

A; liver weight. B; hepatic triglyceride and cholesterol contents. C; hepatic morphology. Arrows indicate hepatic lipid droplets. H&E staining. Original magnification ×200. D; activity of the enzymes for hepatic fatty acid synthesis and esterification. E; activity of the enzymes for hepatic cholesterol synthesis and esterification. F; activity of the enzymes for hepatic fatty acid oxidation and uptake. G; mRNA expression of lipogenic transcription factor and its target gene. The mRNA levels were analyzed by real-time PCR and normalized to an internal control (GAPDH). H; fecal lipids content. Values are the mean ± S.E., n = 10. *p<0.05, **p<0.01, ***p<0.001. ACAT; acyl CoA: cholesterol acyltransferase, ACL; ATP-citrate lyase, CPT; carnitine palmitoyl transferase, DGAT; glyceraldehyde-3-phosphate dehydrogenase, FAS; fatty acid synthase, HMGR; 3-hydroxy-3-methylglutaryl-coenzyme, PAP; phosphatidate phosphohydrolase, PL; powdered persimmon leaf, PPARγ; peroxisome proliferator activated receptor γ, SCD1; steraroyl-CoA desaturase-1.