Table 1. DC50 of CX-4945 and CX-5011.
CEM | CEM* | U2OS | 2008 | LAMA84 | K562 | KCL22 | ||||||||
1% FCS | 10% FCS | 1% FCS | 1% FCS | 10% FCS | 10% FCS | 10% FCS | ||||||||
S | R | S | R | S | R | S | R | S | R | S | R | S | R | |
CX-4945 | 1.92 | 4.09 | 8.62 | 6.50 | 4.58 | 4.33 | 4.87 | 6.56 | 8.55 | 5.79 | 3.41 | 3.72 | 3.30 | 2.95 |
(µM) | ±1.00 | ±0.27 | ±0.68 | ±1.40 | ±0.44 | ±0.63 | ±2.50 | ±0.48 | ±1.10 | ±0.86 | ±0.55 | ±0.42 | ±1.46 | ±0.89 |
CX-5011 | 2.40 | 2.51 | 7.51 | 7.59 | >10 | 8.59 | 2.13 | 2.01 | 5.07 | 2.68 | 3.58 | 3.05 | 3.01 | 3.10 |
(µM) | ±0.07 | ±0.60 | ±2.33 | ±1.35 | ±0.62 | ±0.02 | ±0.21 | ±1.42 | ±0.81 | ±1.18 | ±0.78 | ±1.39 | ±0.86 |