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. 2012 Nov 8;7(11):e49193. doi: 10.1371/journal.pone.0049193

Table 1. DC50 of CX-4945 and CX-5011.

CEM CEM* U2OS 2008 LAMA84 K562 KCL22
1% FCS 10% FCS 1% FCS 1% FCS 10% FCS 10% FCS 10% FCS
S R S R S R S R S R S R S R
CX-4945 1.92 4.09 8.62 6.50 4.58 4.33 4.87 6.56 8.55 5.79 3.41 3.72 3.30 2.95
(µM) ±1.00 ±0.27 ±0.68 ±1.40 ±0.44 ±0.63 ±2.50 ±0.48 ±1.10 ±0.86 ±0.55 ±0.42 ±1.46 ±0.89
CX-5011 2.40 2.51 7.51 7.59 >10 8.59 2.13 2.01 5.07 2.68 3.58 3.05 3.01 3.10
(µM) ±0.07 ±0.60 ±2.33 ±1.35 ±0.62 ±0.02 ±0.21 ±1.42 ±0.81 ±1.18 ±0.78 ±1.39 ±0.86

The values, calculated from 48 h MTT assays reported in Figures 5, 6, 7, 8 (except for CEM* = 24 h treatment), are the mean of 4–6 independent experiments ± Standard Deviation. FCS concentration (v/v) during the treatment is also indicated.