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. 2012 Nov 8;7(11):e49367. doi: 10.1371/journal.pone.0049367

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A, experimental timeline. Cells were labeled with BrdU at 4 weeks after irradiation (i.e. at 3 months of age) with two injections (8 hours apart) and sacrificed 24 hours after the first injection. The expected cell identities (BrdU+ → BrdU+; Dcx+ → NeuN+), if were allowed to continue the maturation process for another month, were also depicted. B, the number of proliferating cells (BrdU+) in the SGZ. C, the number of immature neurons (Dcx+) in the SGZ. Two-way ANOVA with Bonferroni post test was carried out. Radiation was the major source of variation in BrdU (F _(1,21) = 20.13, p = 0.0002) and Dcx (F _(1,16) = 9.30, p = 0.0077) analyses, and there was no genotype×treatment (radiation) interaction. P values indicate results from Bonferroni post tests. Data are presented as mean ± SEM. Sample size (in the order of Sod2+/+/0 Gy, Sod2+/+/5 Gy, Sod2−/+/0 Gy, and Sod2−/+/5 Gy): BrdU, n = 6, 5, 7, and 7; Dcx, n = 6, 5, 4, and 5.