Table 3. Expression of α8 integrin ligands, α-smooth muscle actin (α-sma) and collagen I in the kidney of α8 Integrin underexpressing mice after UUO.

	WT	α8+/−	α8−/−
fibronectin (fold induction)	17.1.82±0.16*	19.45±2.47*	16.69±2.17*
osteopontin (fold induction)	26.14±2.58*	27.25±4.80*	32.08±5.84*
fibrillin-1 (fold induction)	8.46±0.82*	11.63±1.33*	10.14±1.42*
α-sma (fold induction)	2.50±0.409*	3.37±0.44*	4.01±0.42* #
collagen I (fold induction)	30.71±4.91*	33.89±4.16*	35.46±4.49*

UUO, unilateral ureteral obstruction; WT, wild type; α8+/−, mice with a heterozygous deficiency for α8 integrin; α8−/−, mice with a homozygous deficiency for α8 integrin. Values are fold induction of the sham WT control group. Data are means±sem.

^*p<0.05 UUO versus sham,

^#p<0.05 α8−/− versus wild type UUO.