Table 4. Body and organ weights and physiological parameters of wild type and α8 integrin-deficient mice after UUO.

	WT sham	WT UUO	α8+/− sham	α8+/− UUO	α8−/− sham	α8−/− UUO
Body weight (g)	24.27±0.72	25.29±0.55	25.57±0.46	23.58±0.66	23.56±0.69	22.58±57
Rel. left kidney weight (% g/g)	0.552±0.031	0.628±0.022	0.558±0.0150	0.621±0.024	0.433±0.017	0.549±0.027* #
Rel. right kidney weight (% g/g)	0.590±0.010	0.607±0.035	0.594±0.026	0.646±0.038	0.425±0.021	0.522±0.029
Rel. left ventricular weight (% g/g)	0.323±0.006	0.346±0.010	0.328±0.006	0.356±0.021	0.330±0.008	0.346±0.007
Mean arterial pressure (mm Hg)	122.9±3.0	133.6±3.4	123.3±4.69	133.7±6.43	121.6±4.0	123.7±2.5
Albuminuria (µg/d)	0.042±0.009	0.039±0.009	0.038±0.007	0.028±0.005	0.070±0.010	0.053±0.007
Creatinine clearance (ml/min)	0.374±0.103	0.217±0.047	0.246±0.048	0.150±0.023	0.264±0.033	0.179±0.028
Serum creatinine (mg/dl)	0.066±0.007	0.101±0.011	0.076±0.007	0.157±0.039*	0.088±0.007	0.136±0.0143
Serum urea (mg/dl)	60.08±2.50	69.84±6.32	59.06±2.16	74.99±3.20	67.57±5.11	91.39±6.35* , #

WT, wild type; UUO, unilateral ureteral obstruction, α8+/−, mice with a heterozygous deficiency for α8 integrin; α8−/−, mice with a homozygous deficiency for α8 integrin. Data are means±sem.

^*p<0.05 UUO versus sham,

^#p<0.05 α8−/− versus wild type UUO.