Table 1. ChIP-Seq identified GBX2 targets.
Candidate Gene ID | P value | Fold enrichment | Number of tags | Consensus motif | Entrez ID |
NFE2L2 | 2.6×10−270 | 26.18 | 376 | yes | 4780 |
EEF1A1 | 1.2×10−36 | 6.26 | 154 | yes | 1915 |
OTUD7B | 4.1×10−13 | 90.17 | 8 | yes | 56957 |
ULK4 | 1.2×10−12 | 80.17 | 8 | yes | 54986 |
OR5H1 | 3.0×10−10 | 12.72 | 19 | yes | 26341 |
ACSL1 | 2.9×10−9 | 45.09 | 6 | no | 2180 |
ELMO1 | 2.4×10−9 | 42.87 | 7 | no | 9844 |
SOCS4 | 9.7×10−8 | 45.09 | 5 | yes | 122809 |
PPP3CB | 8.9×10−8 | 18.52 | 9 | yes | 5532 |
LAMA2 | 6.2×10−8 | 51.67 | 5 | no | 3908 |
PLXNA4 | 4.3×10−8 | 33.07 | 6 | no | 91584 |
ROBO1 | 3.7×10−8 | 56.36 | 5 | yes | 6091 |
SCFD2 | 3.7×10−8 | 56.36 | 5 | yes | 152579 |
TNFRSF21 | 3.7×10−8 | 56.36 | 5 | no | 27242 |
ERC2 | 3.7×10−8 | 56.36 | 5 | yes | 26059 |
TGFA | 3.7×10−8 | 45.09 | 5 | yes | 7039 |
GUSBL1 | 3.5×10−8 | 39.68 | 6 | yes | 387036 |
VCL | 2.1×10−8 | 24.8 | 7 | yes | 7414 |
SYT2 | 1.7×10−8 | 27.56 | 7 | no | 127833 |
RTN1 | 9.2×10−7 | 15.34 | 8 | yes | 6252 |
PARD3 | 9.0×10−7 | 12.02 | 10 | yes | 56288 |
FGF12 | 8.2×10−7 | 13.23 | 9 | yes | 2257 |
NRP1 | 5.3×10−7 | 15.03 | 7 | yes | 8829 |
BRE | 1.9×10−7 | 45.09 | 5 | yes | 9577 |
SBF2 | 1.8×10−7 | 45.09 | 5 | no | 81846 |
IL1RAP | 1.2×10−7 | 45.09 | 5 | no | 3556 |
MYST4 | 1.1×10−7 | 22.05 | 7 | yes | 23522 |
NOTCH2 | 9.1×10−6 | 14.7 | 6 | yes | 4853 |
PCDH15 | 7.3×10−6 | 19.84 | 5 | yes | 65217 |
GRIA1 | 5.3×10−6 | 8.27 | 9 | yes | 2890 |
USH2A | 3.6×10−6 | 13.78 | 6 | yes | 7399 |
KCNB2 | 2.5×10−6 | 15.31 | 7 | yes | 9312 |
SLIT3 | 1.4×10−6 | 21.2 | 6 | no | 6586 |
TBC1D5 | 1.2×10−6 | 2.98 | 82 | yes | 9779 |
Genes targeted by GBX2 in human PC-3 cells based on ChIP-Seq fragments aligned to the hg18 build of the human genome on the UCSC Human Genome Browser. Bold text indicates GBX2 targets expressed in the nervous system.