Table 5. Probability values for differences in pathogenicity measures between the WT and recombinant S. pneumoniae strains.
p-values | ||||||||
Strain comparison | Day 1 Otoscopy Either ear | Day 2 Otoscopy Either ear | Rapidity of Developing Ear Fluid | Maximal Otologic Score | Time to Maximal Otologic Score | Overall Mortality@ | Spread to Lung@ | Spread to Brain@ |
SV35-T23 vs. SV36-T3 | 0.0008 | 0.0002 * | 0.0019 * | 0.0019 * | NC | 1.1−05 | 0.0058 | 0.023 |
SV35-T3* vs. SV36-T3 | 0.0387 | 0.0031 * | 0.298* | 0.1806* | NC | 0.0823 | 0.3348 | 1 |
Italicized values are statistically significant at P≤0.05.
computed using the Mann-Whitney U (Wilcox) Test;
computed using the Fisher Exact Test for Count Data, NC = not computed.