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. Author manuscript; available in PMC: 2013 Oct 31.
Published in final edited form as: J Am Chem Soc. 2012 Oct 19;134(43):18132–18138. doi: 10.1021/ja308188z

Figure 3.

Figure 3

Spatial proximity of the NADPH and substrate binding sites (stereographic views). In both panels, the view is from the outside of the enzyme looking into the active site. (A) The active site surface of AfUGMo-NADPH. FAD and NADPH are colored yellow and pink, respectively. For reference, the AfUGMo-NADPH structure has been overlaid with the AfUGMr-UDP-Galp complex (PDB code 3uth20) and the UDP-Galp (green) included in this image. The dashed yellow line denotes the 6.3 Å distance between the adenine and uracil sites. (B) The active site surface of AfUGMr. For reference, the AfUGMo-NADPH structure has been overlaid with AfUGMr and the NADPH (pink) included in this image. Note that the adenosine pocket is also present in the reduced enzyme.