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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Hepatology. 2012 Dec;56(6):2316–2327. doi: 10.1002/hep.25938

Fig. 3. Enhanced liver fibrosis in SOD1mu mice is suppressed by inhibition of NOX1/4 with GKT137831.

Fig. 3

Livers from WT or SOD1mu mice were analyzed after 12 injections of CCl4 or vehicle (n=5). In last half period of injections, some mice in each strain were treated by NOX1/4 inhibitor daily. (A) Fibrillar collagen deposition was evaluated by sirius red staining (original magnification ×40), and (B) its quantification is shown. The expression of a-SMA in the liver was detected by (C) immunohistochemistry staining and (D) Western blotting (original magnification ×100). (E) Hepatic expression of collagen α1(I), TIMP-1 and TGF-β1 mRNA was measured by quantitative real-time PCR. NI: NOX1/4 inhibitor. *P<0.05