. Author manuscript; available in PMC: 2013 Nov 8.

Published in final edited form as: J Med Chem. 2012 Sep 6;55(21):9195–9207. doi: 10.1021/jm3008823

Table 2.

BACE 1 inhibitory and cellular activity of inhibitors 18–22.

Entry	K_i (nM)	IC₅₀ (nM)^a
1	7.3	22
2	0.4	---
3	0.036	15
4	7.2	---
5	0.47	14

IC₅₀ was determined in neuroblastoma cells. GRL-8234 exhibited K_i = 1.8 nM, IC₅₀ = 2.5 nM in this assay.