Skip to main content
. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2012 Aug 29;21(11):2022–2032. doi: 10.1158/1055-9965.EPI-12-0759

Table 4.

Association of baseline estrogen metabolite levels with breast cancer risk by ER/PR status among women in the WHI Hormone Trials

Estrogen receptor (ER) Progesterone Receptor (PR) Status
ER+/PR+ ER-/PRN
N case/
control		 Median (IQR) OR (95% CI) p N Case/
Control		 Median (IQR) OR (95% CI) p
16α-OHE1(pg/ml) 16α-OHE1(pg/ml)
Quartile 1a 78/423 239.5 (212.3-257.5) graphic file with name nihms-403757-t0004.jpg 0.09d Quartile 1a 18/423 238.8 (211.0, 257.0) graphic file with name nihms-403757-t0005.jpg 0.86d
Quartile 2a 109/420 309.5 (291.0-327.0) Quartile 2a 23/420 309.5 (291.0, 326.5)
Quartile 3a 115/425 378.0 (358.0-398.0) Quartile 3a 20/425 377.5 (359.0, 398.0)
Quartile 4a 97/422 492.0 (450.5-570.0) Quartile 4a 17/422 491.5 (450.5, 569.0)
Continuousa 1.23 (0.87-1.74) 0.24 Continuousa 0.75 (0.36-1.59) 0.46
Continuousb 1.12 (0.79-1.59) 0.53 Continuousb 0.75 (0.35-1.58) 0.44
Continuousc 1.17 (0.82-1.67) 0.40 Continuousc 0.77 (0.36-1.64) 0.50
2-OHE1(pg/ml) 2-OHE1(pg/ml)
Quartile 1a 86/428 60.0 (49.0, 69.0) graphic file with name nihms-403757-t0006.jpg 0.12d Quartile 1a 17/428 59.5 (48.5, 69.0) graphic file with name nihms-403757-t0007.jpg 0.35d
Quartile 2a 94/420 88.5 (82.0, 93.5) Quartile 2a 25/420 88.5 (82.0, 93.5)
Quartile 3a 105/419 116.0 (107.5,
125.0)		 Quartile 3a 15/419 115.5 (107.3, 125.0)
Quartile 4a 114/423 174.5 (151.5,
227.0)		 Quartile 4a 21/423 174.0 (153.0, 228.5)
Continuousa 1.35 (1.09-1.68) 0.006 Continuousa 1.15 (0.75-1.76) 0.54
Continuousb 1.34 (1.08-1.66) 0.008 Continuousb 1.12 (0.73-1.73) 0.60
Continuousc 1.31 (1.05-1.63) 0.02 Continuousc 1.13 (0.72-1.75) 0.60
2:16 ratio 2:16 ratio
Quartile 1a 87/420 0.17 (0.13-0.19) graphic file with name nihms-403757-t0008.jpg 0.48d Quartile 1a 24/420 0.17 (0.13-0.19) graphic file with name nihms-403757-t0009.jpg 0.31d
Quartile 2a 99/422 0.26 (0.24-0.28) Quartile 2a 11/422 0.26 (0.24-0.28)
Quartile 3a 107/422 0.35 (0.32-0.38) Quartile 3a 19/422 0.35 (0.33-0.38)
Quartile 4a 102/421 0.53 (0.47-0.67) Quartile 4a 24/421 0.53 (0.47-0.67)
Continuousa 1.21 (0.99-1.49) 0.06 Continuousa 1.22 (0.82-1.82) 0.33
Continuousb 1.24 (1.01-1.53)e 0.04 Continuousb 1.20 (0.81-1.79) 0.37
Continuousc 1.20 (0.98-1.49) 0.08 Continuousc 1.20 (0.79-1.81) 0.39

All models account for age and ethnicity matching. Estrogen metabolite levels are log-transformed for continuous models.

a

Unadjusted

b

Adjusted for BMI

c

Adjusted for BMI and treatment arm

d

p-value for Wald Χ2 test for differences among quartiles

IQR=interquartile range

OR=odds ratio

CI=confidence interval