Table 2. Protein expression in hormone naive and castrate-resistant tumours.
| HNPC (IQR) | CRPC (IQR) | P -value | ICCC | Histoscore units | |
|---|---|---|---|---|---|
| p65, c | 100 (140–180) | 100 (150–180) | 0.755 | 0.86 | 40 |
| NLS, c | 163 (139–192) | 196 (173–210) | 0.003 | 0.8 | 57 |
| NLS, n | 90 (50–124) | 102 (50–137) | 0.037 | 0.8 | 45 |
| pp65ser276, c | 0 (0–41) | 0 (0–30) | 0.010 | 0.77 | 64 |
| pp65ser276, n | 7 (50–80) | 50 (70–92) | 0.544 | 0.85 | 42 |
| pp65ser536, c | 70 (100–120) | 42 (90–123) | 0.276 | 0.83 | 80 |
| pp65ser536, n | 0 (20–73) | 0 (40–80) | 0.159 | 0.85 | 55 |
| pIκBαser32/36, c | 110 (116–196) | 133 (160–186) | 0.392 | 0.80 | 80 |
| pIκBαser32/36, n | 194 (150–220) | 196 (136–228) | 0.963 | 0.93 | 55 |
| MMP-9 | 80 (120–170) | 90 (120–160) | 0.922 | 0.83 | 80 |
Abbreviation: ICCC=interclass correlation coefficient.
The median histoscore and interquartile range (IQR) for hormone naive tumours (HNPC) and castrate-resistant tumours (CRPC) and the P-value of these values compared using a Wilcoxon sign rank test. The mean difference in observer scores plus 2 standard deviations is also shown as the number of histoscore units that is defined as a change in protein expression (change). c and n relates to protein cellular location, c=cytoplasm and n=nucleus. P before a protein indicates that the antibody detects phosphorylated protein and the number following the protein represents the site of phosphorylation.