Table 1. Patient characteristics and toxicity by 5FU treatment regimen.
| Treatment regimen | ||
|---|---|---|
| Mayo daily schedule | Weekly schedule | |
| n =42 | n =31 | |
| 5FU (mg m−2) | 425 | 500 |
| LV (mg m−2) | 20 | 20 |
| Schedule | Daily for 5 days every 4 weeks | Weekly for 4 weeks |
| Gender, n (%) | ||
| Male | 24 (57) | 18 (58) |
| Female | 18 (43) | 13 (42) |
| Age (years) | 62 (58–66) | 64 (54–72) |
| CRC, n (%) | ||
| Stage B | 5 (12) | 6 (19) |
| Stage C | 37 (88) | 25 (81) |
| Platelet nadir (109 l−1) | 231 (196–269) | 236 (215–258) |
| WBC nadir (109 l−1) | 3.7 (2.6–4.7) | 4.8 (4.1–6.4) |
| ANC nadir (109 l−1) | 0.7 (0.3–2.0) | 2.6 (1.7–3.7) |
| Thrombocytopenia, n (%) | ||
| Grade 4 | 1 (2) | 0 (0) |
| Leukopenia, n (%) | ||
| Grade 1 | 4 (10) | 3 (10) |
| Grade 2 | 11 (27) | 1 (3) |
| Grade 3 | 3 (7) | 1 (3) |
| Grade 4 | 1 (2) | 0 (0) |
| Neutropenia, n (%) | ||
| Grade 1 | 2 (5) | 6 (19) |
| Grade 2 | 5 (12) | 2 (6) |
| Grade 3 | 8 (20) | 1 (3) |
| Grade 4 | 13 (32) | 0 (0) |
| Haematological toxicity | ||
| ⩾Grade1 | 29 (70) | 10 (32) |
| Febrile neutropenia, n (%) | ||
| Grade 3 | 1 (2) | 1 (3) |
| Grade 4 | 2 (5) | 0 (0) |
| Mucositis, n (%) | ||
| Grade 1 | 4 (10) | 2 (6) |
| Grade 2 | 15 (36) | 2 (6) |
| Grade 3 | 5 (12) | 0 (0) |
| Diarrhoea, n (%) | ||
| Grade 1 | 17 (40) | 8 (26) |
| Grade 2 | 3 (7) | 3 (10) |
| Grade 3 | 2 (5) | 2 (6) |
Abbreviations: 5FU=5-Fluorouracil; ANC=absolute neutrophil count; CRC=colorectal cancer; LV=leucovorin; WBC=white blood count.
Values for non categorical data are median (lower–upper quartile).