Table 1. Patients’ characteristic.
BM and ECM (
n
=184)
|
BO (
n
=38)
|
||||
---|---|---|---|---|---|
Characteristic | n | % | n | % | χ2 Test/t-test |
Age at first diagnosis of breast cancer (years) | |||||
Median | 48.5 | 52 | 0.92 | ||
Range | 26–79 | 34–79 | |||
Breast cancer subtype | |||||
Luminal | 45 | 24.5 | 13 | 34.2 | 0.19 |
Her2-positive | 92 | 50.0 | 13 | 34.2 | |
Triple-negative | 47 | 25.5 | 12 | 31.6 | |
Stage IV at first diagnosis | |||||
Yes | 26 | 14.2 | 1 | 2.6 | 0.5 |
No | 157 | 85.8 | 37 | 97.4 | |
Chemotherapy before diagnosis of BM | |||||
Yes | 169 | 91.8 | 33 | 86.8 | 0.33 |
No | 15 | 8.2 | 5 | 13.2 | |
Her2-targeted therapy before BM | |||||
Yes | 70 | 76.1 | 7 | 53.8 | 0.90 |
No | 22 | 23.9 | 6 | 46.2 | |
Age at first diagnosis of BM (years) | |||||
Median | 52.5 | 54.5 | 0.48 | ||
Range | 26–81 | 36–83 | |||
Time to BM from first diagnosis of breast cancer (months) | |||||
Median | 41.0 | 30.0 | 0.02 | ||
Range | 0–200 | 0–116 | |||
Number of BM | |||||
Mean | 3 | 2 | 0.36 | ||
Range | 1–20 | 1–8 | |||
Karnofsky performance status at first diagnosis of BM | |||||
>70 | 167 | 90.8 | 36 | 94.7 | 0.43 |
<70 | 17 | 9.2 | 2 | 5.3 | |
DS-GPA | |||||
Class I | 43 | 23.4 | 6 | 15.8 | |
Class II | 81 | 44.0 | 18 | 47.4 | |
Class III | 51 | 27.7 | 12 | 31.6 | 0.78 |
Class IV | 9 | 4.9 | 2 | 5.3 | |
Metastatic pattern at first diagnosis of BM | |||||
Visceral metastases | 129 | 58.1 | 0 | 0 | — |
Lung metastases | 86 | 38.7 | 0 | 0 | |
Liver metastases | 79 | 35.6 | 0 | 0 | |
Lymph metastases only | 5 | 2.3 | 0 | 0 | |
Bone metastases only | 7 | 3.2 | 0 | 0 | |
First-line treatment for BM | |||||
Radiosurgery | 19 | 10.3 | 3 | 7.9 | 0.002 |
Chemotherapy | 1 | 0.5 | 1 | 2.6 | |
Surgery | 71 | 38.6 | 27 | 71.1 | |
WBRT | 88 | 47.8 | 7 | 18.4 | |
Best supportive care | 5 | 2.7 | 0 | 0 | |
Chemotherapy after diagnosis of BM | |||||
Yes | 77 | 41.8 | 8 | 21.1 | 0.016 |
No | 107 | 58.2 | 30 | 78.9 | |
Systemic progression after treatment for BM | |||||
Yes | 84 | 45.7 | 0 | 0 | — |
No | 100 | 54.3 | 38 | 100 | |
BM progression | |||||
Yes | 62 | 33.7 | 14 | 36.8 | 0.71 |
No | 122 | 66.3 | 24 | 63.2 | |
OS from diagnosis of BM (months) | |||||
Median | 6 | 11 | 0.007 | ||
Range | 0–104 | 0–69 | |||
Survival beyond 3 years | |||||
Yes | 5 | 2.7 | 7 | 18.4 | <0.001 |
No | 179 | 97.3 | 31 | 81.6 |
Abbreviations: BM=brain metastases; BO=brain-only; DS-GPA=diagnosis-specific graded prognostic assessment; ECM=extracranial metastases; OS=overall survival; WBRT=whole brain radiotherapy.