Table II.

Summary ORs and 95% CIs of RANTES gene polymorphisms and pediatric asthma risk.

Subgroup	Genetic model	Sample size		Type of model	Heterogeneity		Association		Publication bias
		Case	Control		I2 (%)	P-value	OR	95% CI	z	P-value
−403G/A
Overall	AA vs. GG	973	935	Fixed	0.0	0.98	1.34	0.95–1.89	0.00	1.00
	AA vs. GA			Fixed	0.0	0.75	1.18	0.84–1.66	0.00	1.00
	Dominant			Fixed	0.0	0.94	0.81	0.59–1.11	0.00	1.00
	Recessive			Fixed	3.6	0.39	1.06	0.87–1.29	0.00	1.00
Caucasian	AA vs. GG	304	477	Fixed	0.0	0.95	1.27	0.52–3.13	0.00	1.00
	AA vs. GA			Fixed	0.0	0.62	1.66	0.65–4.24	0.00	1.00
	Dominant			Fixed	0.0	0.86	0.73	0.30–1.80	0.00	1.00
	Recessive			Fixed	22.2	0.26	0.84	0.60–1.17	0.00	1.00
Asian	AA vs. GG	669	458	Fixed	0.0	0.87	1.35	0.93–1.96	0.34	1.00
	AA vs. GA			Fixed	0.0	0.61	1.12	0.78–1.62	0.34	1.00
	Dominant			Fixed	0.0	0.75	0.82	0.58–1.15	0.34	1.00
	Recessive			Fixed	0.0	0.81	1.21	0.95–1.54	0.34	1.00
−28C/G
Overall	GG vs. CC	800	785	Fixed	30.0	0.23	1.53	0.81–2.90	0.24	1.00
	GG vs. CG			Random	82.5	0.00	4.93	0.48–50.53	0.24	1.00
	Dominant			Fixed	26.4	0.25	0.69	0.37–1.29	0.24	1.00
	Recessive			Fixed	13.7	0.33	1.34	1.04–1.72	0.24	1.00
Asian	GG vs. CC	640	482	Fixed	30.0	0.23	1.53	0.81–2.90	1.02	0.31
	GG vs. CG			Random	82.5	0.00	4.93	0.48–5053	1.02	0.31
	Dominant			Fixed	26.4	0.25	0.69	0.37–1.29	1.02	0.31
	Recessive			Fixed	28.6	0.24	1.30	1.00–1.70	1.02	0.31

OR, odds ratio; CI, confidence interval; RANTES, regulated upon activation, normal T cells expressed and secreted.