Table I.
Author (Refs.) | Site | Group | Source | Sample | Genotype
|
Genotyping method | P-value (HWE) for controls | Adjustment | ||
---|---|---|---|---|---|---|---|---|---|---|
c1/c1 | c1/c2 | c2/c2 | ||||||||
Lin et al (16) | Linxian County, Henan Province | T | ESCC and EAC | 45 | 36 | 6 | 3 | PCR-RFLP | 0.345 | Age, gender |
C | PB | 45 | 20 | 22 | 3 | |||||
Tan et al (17) | Linxian County, Henan Province | T | ESCC | 150 | 107 | 31 | 12 | PCR-RFLP | 0.009 | Age, gender, smoking |
C | PB | 150 | 66 | 77 | 7 | |||||
Shi (20) | Linzhou City, Henan Province | T | EC | 116 | 74 | 37 | 5 | PCR-RFLP | 0.922 | Age, gender, smoking, fermented vegetable |
C | HB | 106 | 46 | 48 | 12 | |||||
Xi’an City, Shaanxi Province | T | EC | 71 | 39 | 28 | 4 | PCR-RFLP | 0.368 | ||
C | HB | 62 | 30 | 24 | 8 | |||||
Gao et al (21) | Huai’an City, Jiangsu Province | T | EC | 144 | 83 | 44 | 13 | PCR-RFLP | 0.525 | Age, gender, tea, smoking, alcohol |
C | PB | 233 | 140 | 75 | 14 | |||||
Shi et al (23) | Wuhan City, Hubei Province | T | EC | 98 | 72 | 19 | 7 | PCR-RFLP | 0.039 | Age, gender |
C | HB | 120 | 54 | 45 | 21 | |||||
Gao et al (22) | Huai’an City, Jiangsu Province | T | EC | 93 | 55 | 31 | 7 | PCR-RFLP | 0.20 | Age, gender, smoking, drinking, dietary habits |
C | PB | 196 | 121 | 62 | 13 | |||||
Shi et al (24) | Nanjing City, Jiangsu Province | T | EC | 78 | 48 | 24 | 6 | PCR-RFLP | 0.141 | Age, gender, smoking, alcohol |
C | HB | 118 | 60 | 42 | 16 | |||||
Yin et al (25) | Huai’an City, Jiangsu Province | T | EC | 106 | 52 | 49 | 5 | PCR-RFLP | 0.411 | Age, gender |
C | HB | 106 | 55 | 45 | 6 | |||||
Lu et al (19) | Kazakh, Xinjiang Autonomous Region | T | ESCC | 104 | 81 | 20 | 3 | PCR-RFLP | <0.001 | Age, gender |
C | PB | 104 | 25 | 74 | 5 | |||||
Li (26) | Taiyuan City, Shanxi Province | T | EC | 60 | 32 | 18 | 10 | PCR-RFLP | 0.781 | Age, gender, smoking, drinking habits |
C | PB | 199 | 101 | 69 | 29 | |||||
Liu et al (28) | Huai’an City, Jiangsu Province | T | ESCC | 77 | 34 | 33 | 10 | PCR-RFLP | 0.91 | Age, gender |
C | PB | 79 | 45 | 29 | 5 | |||||
Dong et al (27) | Gansu Province | T | EC | 120 | 84 | 26 | 10 | PCR-RFLP | 0.428 | Age, gender |
C | HB | 120 | 57 | 44 | 19 | |||||
Xia et al (31) | Jingjiang City, Jiangsu Province | T | ESCC | 45 | 30 | 12 | 3 | PCR-RFLP | 0.708 | Not reported |
C | HB | 45 | 26 | 17 | 2 | |||||
Qin et al (30) | Kazakh, Xinjiang Autonomous Region | T | EC | 120 | 94 | 23 | 3 | PCR-RFLP | 0.29 | Age, gender, dietary habits |
C | PB and HB | 240 | 128 | 90 | 22 | |||||
Guo et al (29) | Lanzhou City, Gansu Province | T | ESCC | 80 | 57 | 16 | 7 | PCR-RFLP | <0.001 | Age, gender |
C | PB | 480 | 225 | 180 | 75 | |||||
Yang (32) | Feicheng City, Shandong Province | T | ESCC | 27 | 19 | 8 | 0 | PCR-RFLP | 0.442 | Age, gender, alcohol, education, smoking |
C | PB | 44 | 31 | 11 | 2 | |||||
Zhang and Wu (33) | Gansu Province | T | EC | 129 | 75 | 40 | 14 | PCR-RFLP | 0.443 | Age, gender |
C | PB | 156 | 70 | 56 | 21 |
Characteristics of studies included in this meta-analysis. T, case subjects; C, control subjects; PB, population-based; HB, hospital-based; ESCC, esophageal squamous cell carcinoma; EAC, esophageal adenocarcinoma; EC, esophageal cancer; HWE, Hardy-Weinburg equilibrium; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism.