Table III.
Sensitivity analysis after elimination of the studies where frequency distributions of genotypes in the controls were inconsistent with HWE.
| Heterogeneity
|
Meta-analyses
|
|||||
|---|---|---|---|---|---|---|
| Genetic model | Subgroup | P-value | I2 (%) | OR (95% CI) | P-value | Model |
| c2 vs. c1 | Total | <0.001 | 80 | 0.64 (0.50, 0.81) | 0.0003 | Random |
| AE | <0.001 | 71 | 0.76 (0.60, 0.96) | 0.02 | Random | |
| c2/c2 vs. c1/c1 | Total | 0.03 | 42 | 0.70 (0.56, 0.89) | 0.003 | Fixed |
| AE | 0.08 | 37 | 0.75 (0.57, 0.98) | 0.03 | Fixed | |
| c1/c2 vs. c1/c1 | Total | <0.001 | 81 | 0.54 (0.38, 0.75) | 0.0003 | Random |
| AE | 0.001 | 62 | 0.71 (0.54, 0.93) | 0.01 | Random | |
| c2/c2 vs. c1/c1+c1/c2 | Total | 0.12 | 29 | 0.73 (0.58, 0.92) | 0.008 | Fixed |
| AE | 0.19 | 24 | 0.77 (0.59, 1.00) | 0.05 | Fixed | |
| c1/c2+c2/c2 vs. c1/c1 | Total | <0.001 | 85 | 0.48 (0.34, 0.70) | 0.0001 | Random |
| AE | <0.001 | 80 | 0.62 (0.43, 0.89) | 0.01 | Random | |
Sensitivity analysis after elimination of the studies for which the frequency distributions of genotypes in the controls were inconsistent with HWE. AE, after elimination; HWE, Hardy-Weinburg equilibrium; OR, odds ratio; CI, confidence interval.