Table 3.

Age-defined population-specific thresholds for HE4, CA125, and the ROMA Predictive Index yielding 90%, 95%, 98% and 99% specificity. For CA 125 the reference range is applicable to all women in the age-range indicated. Thresholds for HE4 for a woman whose age is not presented in the table can be calculated by linear interpolation between the ln(threshold) values.

Marker	Age	Mean	90% Specificity	95% Specificity	98% Specificity	99% Specificity
CA125 (U/ml)	age < 45	13.428	26.306	31.830	39.447	45.513
	45 ≤ age < 55	12.023	23.553	28.500	35.320	40.751
	age ≥ 55	9.370	18.356	22.211	27.526	31.759
HE4 (pmol/L)	30	25.522	37.216	41.417	46.714	50.617
	40	27.703	40.398	44.957	50.707	54.944
	50	29.312	42.744	47.568	53.652	58.135
	60	31.306	45.651	50.804	57.302	62.089
	70	39.796	58.033	64.583	72.843	78.929
	80	50.590	73.772	82.098	92.599	100.335
ROMA Predictive Index	30	0.016	0.035	0.044	0.056	0.067
	40	0.020	0.043	0.054	0.069	0.081
	50	0.037	0.081	0.101	0.130	0.154
	60	0.056	0.123	0.154	0.197	0.233
	70	0.074	0.162	0.202	0.259	0.306
	80	0.097	0.212	0.265	0.340	0.402