Table 2.

Identification of anatomy, BA, hemispheric location (L/R), and coordinates (x,y,z) in MNI space for regions in which LTAA showed significantly different RSS (manifested as significantly different z-scores that survived thresholding [p<0.05 familywise and p<0.001 voxelwise] and clustering to correct for multiple comparisons, see methods section for specifics) than NSAC within (A) the NAcc map and (B) the subgenual ACC map after first-level group analysis. Regions in which LTAA showed higher strength of RSS are in italics, regions in which LTAA showed lower strength of RSS have normal font. Regions with asterisks (* or **) are regions that remained to be significantly different between groups after second-level group analysis (ANCOVA). F-value, significance and effect size presented show ANCOVA analysis results. BA, Brodmann Area; L, left; R, right; MNI, Montreal neurological institute; LTAA, long-term abstinent alcoholics; RSS, resting state synchrony; NSAC, non-substance abusing controls; NAcc, nucleus accumbens; ACC, anterior cingulate cortex; ANCOVA, analysis of covariance.

(A) NAcc
Anatomy of region	L/R	x	y	z	F	Significance	Effect size -partial eta²
Dorsolateral prefrontal cortex, BA 10^*	L	−27	61	26	5.66	0.022^*	0.13^*
Superior frontal gyrus, BA 6	R	23	29	59	3.90	0.056	0.09
Caudate^*	L	−12	−1	15	4.29	0.045^*	0.10
Caudate^*	R	11	3	11	4.29	0.045^*	0.10
Anterior nucleus of thalamus^**	L	−10	−14	16	8.30	0.006^*	0.18^**
Anterior nucleus of thalamus^**	R	10	13	14	8.30	0.006^*	0.18^**
Medial dorsal thalamus^*	L	−6	−25	5	5.00	0.031	0.12^*
Medial dorsal thalamus^*	R	8	−21	7	5.00	0.031	0.12^*
Postcentral gyrus, BA 2	L	−46	−30	44	2.84	0.100	0.07
Postcentral gyrus, BA 2	R	46	−31	40	2.84	0.100	0.07
Inferior parietal lobule, BA 40^*	L	−36	−54	59	4.45	0.041^*	0.11^*

(B) Subgenual ACC
Anatomy of region	L/R	x	y	z	F	Significance	Effect size -partial eta²
Dorsolateral prefrontal cortex, BA 8^**	R	26	28	54	7.99	0.007^**	0.17^**
Dorsolateral prefrontal cortex, BA 46^**	R	52	34	20	7.99	0.007^**	0.17^**
Caudate	L	−12	8	12	3.01	0.091	0.07
Caudate	R	12	4	11	3.01	0.091	0.07
Medial dorsal thalamus^**	L	−12	2	12	8.44	0.006^**	0.18^**
Medial dorsal thalamus^**	R	6	−2	10	8.44	0.006^**	0.18^**

p<0.05,

^**

p<0.01; Regions in which z-scores remained to be significantly different between groups after second level analysis (ANCOVA).