Table 2. Multivariate analyses of characteristics associated with RFS and CSS in colon cancer tumours stage II and III successfully stained for cyclin D1a.
| RFS | CSS | |||||
|---|---|---|---|---|---|---|
| Characteristic | HR | 95% CI | P | HR | 95% CI | P |
| Stage | ||||||
| Stage III vs II | 4.621 | 2.717–7.862 | <0.001 | 2.789 | 1.406–5.533 | 0.003 |
| Tumour localisation | ||||||
| Distal colon vs proximal colon | 1.468 | 0.894–2.408 | NS | 1.194 | 0.711–2.004 | NS |
| Hist.grade | ||||||
| Poor vs high/moderate diff. | 1.436 | 0.790–2.612 | NS | 1.224 | 0.648–2.312 | NS |
| Treatment group | ||||||
| Adjuvant vs surgery alone | 1.454 | 0.750–2.819 | NS | 1.327 | 0.675–2.609 | NS |
| Cyclin D1a status | ||||||
| High vs low | 1.649 | 0.822–3.307 | NS | 0.322 | 0.085–1.221 | 0.096 |
| Interaction | ||||||
| Treatment*cyclin D1a status | 0.222 | 0.080–0.618 | 0.004 | 0.290 | 0.098–0.857 | 0.025 |
| Interaction | ||||||
| Stage*cyclin D1a statusa | — | — | — | 6.634 | 1.621–27.143 | 0.008 |
Abbreviations: CI=confidence interval; HR=hazard ratio; NS=not statistically significant.
a
The interaction variable stage*cyclinD1a was not significant and thus not included in the model for RFS.