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. 2012 Sep 24;287(46):38482–38494. doi: 10.1074/jbc.M112.386912

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Vitamin D receptor signaling is required for effects of vitamin D on monocyte adhesion. Monocytes from type 2 diabetics were differentiated into macrophages and then infected with either VDR-siRNA or control-siRNA lentivirus in 1,25(OH)₂D₃-supplemented media. A, ER stress protein expression. B, macrophage phenotype ratio (inset; *, p < 0.05 versus VDR siRNA) and flow cytometry quantification of membrane receptors CCR7 (white), CD86 (light gray), CD163 (dark gray), and MR (black) (n = 12/group; *, p < 0.05 versus same receptor in VDR siRNA). C, absorbance of macrophages adhered to fibronectin (n = 9/group; *, p < 0.001 versus VDR siRNA). D–F, qPCR for mRNA of adhesion molecules PSGL-1 (D), β₁-integrin (E), and β₂-integrin (F; n = 6/group; *, p < 0.05 for all, versus VDR siRNA) relative to L32.