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Schematic representation of the fluorescence-based screen using the Aβ42-GFP fusion. In the absence of inhibition, the Aβ42 portion of the fusion aggregates rapidly and causes the entire Aβ42-GFP fusion to misfold and aggregate. Therefore, no fluorescence is observed. However, inhibition of Aβ42 aggregation by a small molecule enables GFP to form its native green color.
