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a, improved locomotive ability of 2-week-old flies expressing Aβ42 in their CNS treated with 20 μm D737 versus the DMSO control. b, fraction of flies climbing as a function of time for Drosophila flies expressing Aβ42. Flies were fed DMSO (gray bars) or 20 μm D737 (black bars). c, similar to b for flies expressing the Aβ42(E22G) mutant. Assays using lower and higher concentrations of D737 are shown in supplemental Fig. 4.
