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Increased Cdk1/cyclin B1 activity in Taxol-treated HT29 versus DLD-1 cells. HT29 or DLD-1 cells were synchronized by single thymidine block and treated after 4.5 h with the indicated concentration of Taxol for 16 h. Cell extracts were subjected to Cdk1/cyclin B1 assay, as described under “Experimental Procedures.” Values have been corrected for background kinase activity (mean ± S.D.; n = 3). *** = p < 0.001 (Student's t test).
