TABLE 1.

Amino acid changes within XRCC1 that disrupt interactions with protein partners

The regions of XRCC1 (middle column) that interact with the DNA repair proteins (left column), APE1 (20), PARP1 (23), Polβ (13), PNKP (26), and DNA ligase IIIα (9, 11). The DNA sequence changes and resultant amino acid changes in XRCC1 that disrupt binding to the indicated partner protein are shown in the right column.

XRCC1 interacting protein	Binding region in XRCC1	Amino acid change
APE1	183–404	Glycine 297 (GGC) to valine (GTC)
PARP1	315–403	Leucine 316 (CTG) to arginine (CGG)
Pol β	84–183	Alanine 160 (GCC) to serine (TCC)
PNKP	403–538	Alanine 482 (GCG) to threonine (ACG)
Ligase IIIα	538–633	Proline 623 (CCT) to serine (TCT)