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. 2012 Jun 29;56(3):e26. doi: 10.4081/ejh.2012.e26

Table 1. The known polarized molecules at the canalicular membrane of hepatocytes.

Species Proteins Functions Expression Molecular mass (kDa)
Enzymes
 Rat/human Alkaline phosphatase(ALP) Phosphatase Epithelia and other cells 63
 Rat/human Dipeptidylpeptidase IV (DPP IV)/CD 26 Ectopeptidase Epithelia and other cells 110
 Rat/human B10 Alkaline phosphodiesterase Epithelia 130
 Rat/human HA4/pp120 cell-CAM 105 EctoATPase Epithelia 105–115
 Rat/human 5′nucleotidase (5′NT) Nucleotide hydrolase Liver and other cells 72
 Rat/human Aminopeptidase N (APN)/CD 13/LAP Peptidase Epithelia and fibroblasts 140–160
Skeleton proteins
 Rat/human Ezrin Membrane/cytoskeleton link Epithelia and fibroblasts 81
Channel proteins
 Rat/human Aquaporin 8(AQP8) Water channels Liver and other cells 30
Exchangers
 Rat/human Anion exchanger 2(AE2) HCO3-/Cl- anion exchange Epithelia and other cells 160
Transporters
 Rat/human Multidrug resistance-1(MDR1) /P-glycoprotein(P-gp)/ABCB1 Pleiotropic membrane transporter Epithelia and other cells 170
 Human Multidrug resistance-3(MDR3)/ABCB3 Phospholipid transporter Epithelia and other cells 170
 Rat Multidrug resistance-2(Mdr2)/ABCB2 Phospholipid transporter Epithelia and other cells 170
 Rat/human Multidrug resistance-associated protein-2 (MRP2)/ABCC2 Canalicular conjugate export pump Epithelia and other cells 190
 Rat/human Bile salt export pump (BSEP)/Sister of P-glycoprotein(SPGP)/ABCB11 Canalicular efflux of bile salts Epithelia and other cells 160
 Rat/human Breast cancer resistance protein (BCRP) ABCG2 Canalicular conjugate export pump Epithelia and other cells 75
 Rat/human Familial intrahepatic cholestasis-1(FIC1)/ATP8B1 Putative aminophospholipid translocator Liver and other cells 144