Figure 5. Genomic analysis of Rb^F/F;K14creER^TM;p107^−/− tumors correspond to Akt and mTOR inhibition sensitivity.

Sensitivity to AKT inhibitor (a, perifosine) and mTOR (b, temsirolimus) was tested in a collection of human cancer cell lines. Transcriptome differences between sensitive versus resistant lines was compared with Rb^F/F;K14creER^TM;p107^−/− carcinoma signature. Significant transcript overlapping was observed for over- (in red) and under-expressed (in blue) genes in both the mouse signature and the sensitive cells. For each inhibitor, we show the number of sensitive/resistant cell lines tested (columns represent samples, and rows are genes), the number of common genes, and the significance of overlapping (p-val).