Table 1. GSEA analysis of RbF/F;K14creERTM; p107−/− mouse tumors.
| Gene Set Name (N)1 | Number of enriched genes | NES | FDR q-val |
|---|---|---|---|
| KOBAYASHI_EGFR_SIGNALING_24HR_DN (210) | 153 | 2.93 | < 0.00001 |
| BERENJENO_TRANSFORMED_BY_RHOA_UP (474) | 266 | 2.75 | < 0.00001 |
| GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN (70) | 52 | 2.62 | < 0.00001 |
| BENPORATH_PROLIFERATION (116) | 75 | 2.57 | < 0.00001 |
| GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP (152) | 87 | 2.54 | < 0.00001 |
| REN_BOUND_BY_E2F (46) | 32 | 2.44 | < 0.00001 |
| MARKEY_RB1_ACUTE_LOF_DN (213) | 111 | 2.36 | < 0.00001 |
| LE_EGR2_TARGETS_UP (99) | 56 | 2.35 | < 0.00001 |
| VERNELL_RETINOBLASTOMA_PATHWAY_UP (35) | 27 | 2.32 | < 0.00001 |
| EGUCHI_CELL_CYCLE_RB1_TARGETS (18) | 17 | 2.28 | < 0.00001 |
| YU_MYC_TARGETS_UP (37) | 27 | 2.26 | < 0.00001 |
| TANG_SENESCENCE_TP53_TARGETS_DN (35) | 24 | 2.17 | 0.000014 |
| BENPORATH_CYCLING_GENES (487) | 214 | 2.14 | 0.000013 |
| DANG_MYC_TARGETS_UP (109) | 43 | 2.11 | 0.000012 |
| SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP (59) | 24 | 2.09 | 0.000033 |
| SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP (15) | 11 | 2.08 | 0.000042 |
| MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_DN (38) | 25 | 2.05 | 0.000070 |
| SCIAN_CELL_CYCLE_TARGETS_OF_TP53_AND_TP73_DN (22) | 15 | 2.03 | 0.00015 |
| RICKMAN_HEAD_AND_NECK_CANCER_F (48) | 29 | −2.72 | < 0.00001 |
| BERENJENO_TRANSFORMED_BY_RHOA_DN (352) | 191 | −2.71 | < 0.00001 |
| KUNINGER_IGF1_VS_PDGFB_TARGETS_UP (41) | 7 | −2.61 | < 0.00001 |
| GU_PDEF_TARGETS_UP (64) | 33 | −2.26 | 0.00006 |
| WANG_SMARCE1_TARGETS_UP (136) | 76 | −2.15 | 0.00022 |
| TSENG_IRS1_TARGETS_DN (117) | 46 | −2.13 | 0.00023 |
| DAIRKEE_TERT_TARGETS_DN (63) | 29 | −2.11 | 0.00036 |
| SENESE_HDAC2_TARGETS_DN (99) | 47 | −2.11 | 0.00037 |
| THUM_MIR21_TARGETS_HEART_DISEASE_UP (17) | 14 | −2.06 | 0.00054 |
1N: number of genes from each gene set in mouse chip. 2) Shadowed rows represent overlapping of underexpressed genes in mouse tumors
NES: normalized enrichment score.
NES>0: enrichment in tumors; NES<0: enrichment in normal skin.