Table 1.

Nkx2-1 expression in normal and cancerous lung tissues

Tissue and Disease	Disease status	Nkx2-1 expression profile	Reference
Normal tissue	Fetal lung	Epithelial cells	Stahlman et al., 1996
	Adult lung	Alveolar type II cells, Clara cells, and bronchial basal cells	Ikeda et al., 1995; Holzinger et al., 1996
	Thyroid		Kimura et al., 1996
	Diencephalon	Restricted regions of the brain	Stahlman et al., 1996; Kimura et al., 1996
Lung disease	Acute inflammation, oedema, haemorrhage, atelectasis	Reduced or absent	Stahlman et al., 1996
Respiratory dysfunction and recurrent infection		Perturbed expression due to gene deletions, missense mutations or nonsense mutations	Devriendt et al., 1998; Iwatani et al., 2000; Krude et al., 2002; Pohlenz et al., 2002; Doyle et al., 2004
Lung cancer	Adenocarcinoma	High expression	Myong et al., 2003; Tan et al., 2003
	Squamous carcinoma	Low expression or absent	Myong et al., 2003; Tan et al., 2003
	Large cell lung cancer	Low expression or absent	Nakamura et al., 2002
	Small cell lung cancer	High expression	Kwei et al., 2008; Tanaka et al., 2007