Table 1.

Main characteristics of studies included in the meta-analysis

Study	Total number	Median age (year)	Disease stage	Ethnicity	Criterion	Genotype distribution			ORR	HR
						AA	AG	GG
Li et al., 2012	87	59.08	III–IV	Asian	RECIST	53	30	4	Yes	NR
Dong et al., 2012	564	NR	III–IV	Asian	RECIST	33	227	304	NR	Yes
Joerger et al., 2012	131	59.7	IIIB–IV	Caucasian	WHO	17	63	51	Yes	Yes
Zhou et al., 2011	111	NR	IV	Asian	WHO	6	34	71	Yes	NR
Yao et al., 2010	106	61	IIIB–IV	Asian	RECIST	5	41	60	Yes	NR
Qian et al., 2010	107	NR	IIIB–IV	Asian	WHO	59	40	8	Yes	NR
Ding et al., 2010	54	60	IIIB–IV	Asian	WHO	13	10	31	Yes	NR
Sun et al., 2009	87	59	IV	Asian	WHO	4	30	53	Yes	NR
Yao et al., 2009	108	61	IIIB–IV	Asian	WHO	5	43	60	Yes	Yes
Kalikaki et al., 2009	119	119	IIIA/B–IV	Caucasian	RECIST	10	76	33	Yes	Yes
Fan et al., 2008	81	62.9	IIIB–IV	Asian	WHO	4	32	45	Yes	NR
Liu et al., 2008	53	61	I–IV	Asian	RECIST	8	18	27	NR	Yes
Giachino et al., 2007	248	62	IIIA–IV	Caucasian	RECIST	119	100	29	NR	Yes
Gao et al., 2006	57	59	II–IV	Asian	RECIST	31	23	3	Yes	NR
de las Penas et al., 2006	135	62	IIIB–IV	Caucasian	RECIST	51	65	19	NR	Yes
Wang et al., 2004	105	56	IIIB–IV	Asian	WHO	53	42	10	Yes	NR
Gurubhagavatula et al., 2004	103	58	IIIA–IV	Caucasian	RECIST	51	42	10	NR	Yes

NR: no report; RECIST: response evaluation criteria in solid tumours; WHO: World Health Organization; ORR: overall response rate; HR: hazard ratio