Table 1.
Abnormal Mendelian segregation of progeny from a Igf2+m/−p, p53+/− inter-cross in 129J
| Strain | WT | Igf2+/− | Igf2−/− | p53+/− | Igf2+/−, p53+/− | Igf2−/−, p53+/− | p53−/− | Igf2+/−, p53−/− | Igf2−/−, p53−/− | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| p-Value | ||||||||||
| χ2-Value | ||||||||||
| 129 | 15 | 17 | 7 | 24 | 71 | 29 | 18 | 17 | 9 | 207 |
| (12.94) | (25.88) | (12.94) | (25.88) | (51.75) | (25.88) | (12.94) | (25.88) | (12.94) | p < 0.02 | |
| 0.329 | 3.044 | 2.725 | 0.136 | 7.161 | 0.377 | 1.981 | 3.044 | 1.198 | 19.995 | |
| 129B6F2 | 7 | 22 | 5 | 19 | 33 | 12 | 8 | 13 | 7 | 126 |
| (7.88) | (15.75) | (7.88) | (15.75) | (31.5) | (15.75) | (7.88) | (15.75) | (7.88) | p = NS | |
| 0.097 | 2.480 | 1.049 | 0.671 | 0.071 | 0.893 | 0.002 | 0.480 | 0.097 | 5.841 |
Progeny did not segregate according to a normal Mendelian distribution (p < 0.02, χ2-test). In contrast, progeny from the 129B6F1 Igf2+/−, p53+/− inter-cross had a normal Mendelian distribution. Observed (upper), expected (middle, in brackets) and χ2 (lower).