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. 2012 Jun 18;4(8):761–775. doi: 10.1002/emmm.201200244

Figure 2. Effects of genetic loss of SK1 on the lung colonization/metastasis of MB49 murine bladder cancer cells.

Figure 2

  • A,B. Effects of the genetic loss of SK1 on lung colonization/metastasis of MB49/luciferase (A) or MB49 (B) cells were detected in WT and SK1−/− mice via tail vein injections (n = 6/group). Data are represented as mean ± SD. Error bars represent standard deviations. p < 0.05 (*) was considered significant.
  • C-E. Tumour burden in the lungs of WT and SK1−/− mice (n = 10/group) after tail vein injections of MB49 cells were measured by lung weight (C), number of MB49-derived lung tumour colonies (D), and lung tumour scores (E). Data are represented as mean ± SD. Error bars represent standard deviations. p < 0.05 (*) was considered significant.
  • F. Effects of tail vein injections of MB49 cells into WT and SK1−/− mice on systemic S1P (left panel) or dhS1P (right panel) levels were measured by LC/MS/MS. Data are represented as mean ± SD. Error bars represent standard deviations. p < 0.05 (*) was considered significant.