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. 2012 Jun 18;4(8):761–775. doi: 10.1002/emmm.201200244

Figure 7. Brms1 expression plays important roles in the suppression of MB49-derived lung colonization/metastasis in SK1−/− mice.

Figure 7

  • A. Stable knockdown of Brms1 in response to lentiviral vector based expression of shRNAs (against Brms1 compared to non-targeting Scr shRNAs) in MB49 cells was confirmed using Q-PCR (normalized using rRNA levels). Data are represented as mean ± SD. Error bars represent standard deviations. p < 0.05 (*) was considered significant.
  • B,C. Effects of shRNA-mediated knockdown of Brms1 in MB49 cells on lung metastasis (B) and colonization (C) after tail vein injections in WT and SK1−/− mice (n = 8) were measured compared to controls (sh-Scr). Data are represented as mean ± SD. Error bars represent standard deviations. p < 0.05 (*) was considered significant.