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. 2012 Jun 18;4(8):761–775. doi: 10.1002/emmm.201200244

Figure 8. Suppression of MB49-derived lung tumour colonization/metastasis by inhibition of systemic S1P signalling using Sphingomab in WT mice.

Figure 8

  • A,B. Effects of systemic S1P inhibition by Sphingomab compared to IgG control treatment on lung tumour metastasis (A) or colonization (B) were measured in response to tail vein injection of MB49/sh-Scr versus MB49/sh-Brms1 into WT mice (n = 8/group). Expression of Brms1 in lung tumours after tail vein injections of MB49/sh-Scr and MB49/sh-Brms1 cells into WT mice in response to Sphingomab compared to IgG control treatment was detected by IHC (A, lower panel). Data are represented as mean ± SD. Error bars represent standard deviations. p < 0.05 (*) was considered significant.