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. Author manuscript; available in PMC: 2013 Oct 31.
Published in final edited form as: J Am Chem Soc. 2012 Oct 19;134(43):17900–17903. doi: 10.1021/ja3090498

Figure 3.

Figure 3

Proposed biosynthesis of the chaetoviridins and chaetomugilins from C. glbosoum. (A) Biosynthesis of 3–7 by the caz pathway. (B) Domain organization of the HR-PKS CazF and NR-PKS CazM. CazF consists of a ketosynthase (KS), malonyl-CoA:ACP acyltransferase (MAT), dehydratase (DH), methyltransferase (MT), enoyl reductase (ER), ketoreductase (KR) and acyl carrier protein (ACP). CazM consists of a starter-unit:ACP transacylase (SAT), KS, MAT, product template (PT), MT, ACP and reductive domain (R).