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. 2012 Jul 23;11(10):1048–1062. doi: 10.1074/mcp.M112.019547

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 4. — Impact of SIRT1 knockout on selected cellular pathways and protein complexes. SIRT1 modulates acetylation levels on (A) the subunits of the long-patch base excision repair (BER) complex in the DNA repair pathway, (B) Notch co-activator and corepressor complexes in the Notch signaling pathway, (C) the RNA spliceosome in the RNA splicing pathway, (D) the Brd4-PTEFb complex, (E) the NuA4-Kat5 (Tip60) complex, and (F) the Kat7 (Hbo1) protein complex. Each gene is color-coded based on the highest SILAC KO/WT ratios for the gene.