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. 2012 Jul 22;11(10):1036–1047. doi: 10.1074/mcp.M111.011114

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 2. — Biological trends in mESC and mEpiSC nuclear proteomes. A, Top functional categories represented in combined mESC and mEpiSC data sets (using all identified proteins) showing significant representation of proteins involved in embryogenesis and development. B, Proteins with significantly increased expression (p < 0.1; Student's t test) in either mESC and mEpiSC show significant differences in representation of several functional categories. C, Analysis of mutant phenotypes of genes corresponding to mESC and mEpiSC proteins (proteins differentially expressed in mESCs or mEpiSCs with p < 0.1; Student's t test). mESC proteins represent genes with embryonic lethal phenotypes at earlier developmental stages than mEpiSC proteins. Phenotypes are arranged according to developmental stage: (1) Prenatal lethality, (2) embryonic lethality before implantation (E0-E4.5), (3) embryonic lethality before somite formation (E4.5-E8), (4) embryonic lethality before turning of embryo (E8-E9), (5) embryonic lethality during organogenesis (E19-E14), (6) postnatal lethality, (7) absent somites, (8) open neural tube.