Table II. Enriched functional categories and canonical pathways in mESC and mEpiSC intersecting proteins with PluriNet or PluriNetWork.

Union Set (mESC and mEpiSC) overlap with PluriNet		Union Set (mESC and mEpiSC) overlap with PluriNetWork
Functional categories	p value	Functional categories	p value
Connective Tissue Development and Function	1.96E-05	Organismal development	9.48E-20
Organismal Survival	2.20E-05	Embryonic Development	3.41E-09
Embryonic Development	5.53E-05	Tissue development	1.85E-08
Nervous System Development and Function	5.53E-05	Organ development	3.96E-08
Tissue Development	5.53E-05	Hematological System Development and Function	1.68E-07

Canonical pathways	p value	Canonical pathways	p value
Mismatch Repair in Eukaryotes	2.52E-15	DNA Methylation and Transcriptional Repression Signaling	3.8E-21
Cell Cycle Control of Chromosomal Replication	2.89E-15	Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency	2.26E-09
Hereditary Breast Cancer Signaling	8.75E-11	Chronic Myeloid Leukemia Signaling	4.18E-07
Role of CHK Proteins in Cell Cycle Checkpoint Control	4.01E-09	Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency	1.15E-06
Role of BRCA1 in DNA Damage Response	8.21E-09	Huntington's Disease Signaling	1.67E-06