Table IV. Eighteen differentially expressed proteins in the second significant network deduced from nuclear proteome analysis.

Symbol	Recommended name	Protein ratio obtained from nuclear proteome (KPNA2 siRNA/ control siRNA)	Protein ratio obtained from whole proteome (KPNA2 siRNA/ control siRNA)	mRNA ratio obtained from qPCR (KPNA2 siRNA/ control siRNA)	Prediction of cNLS	Unique peptide number	Dysregulated in lung cancer (reference number)
CLSPN	Claspin	0.12	NDa	0.52	Yes	3	Yes (55)
DBF4	Protein DBF4 homolog A	0.27	ND	0.65	Yes	1	Yes (56)
JMJD6	Histone arginine demethylase	0.46	0.63	0.73	Yes	6	No
MCM10	Protein MCM10 homolog	0.28	ND	0.80	Yes	2	No
POLA1	DNA polymerase alpha catalytic subunit	0.35	0.36	0.65	No	14	No
POLA2	DNA polymerase subunit alpha B	0.35	0.53	0.52	Yes	3	No
PRIM2	DNA primase large subunit	0.36	0.62	0.75	No	7	No
UGDH	UDP-gluce 6-dehydrogenase	0.40	0.91	0.57	No	14	No
ATAD2	ATPase family AAA domain-containing protein 2	0.27	0.27	1.03	Yes	15	Yes (57)
BARD1	BRCA1-associated RING domain protein 1	0.43	ND	1.00	Yes	4	No
MYH10	Myin-10	2.39	1.06	1.12	Yes	27	No
NBN	Nibrin	0.47	0.90	1.11	Yes	11	Yes (22)
BLM	Bloom syndrome protein	0.41	ND	UDb	Yes	7	Yes (58)
CDK6	Cell division protein kinase 6	0.32	ND	UD	No	2	Yes (59)
MAT2A	S-adenylmethionine synthetase isoform type-2	0.48	0.94	UD	No	8	No
PAF	PCNA-associated factor	0.29	ND	UD	Yes	2	No
PMS2	Mismatch repair endonuclease	0.41	ND	UD	No	2	No
UHRF1	E3 ubiquitin-protein ligase	0.34	0.33	UD	Yes	27	Yes (52, 60)

^a ND: Protein levels of differentially expressed proteins were not determined in whole proteome analysis.

^b UD: mRNA levels of differentially expressed proteins were unable to be detected by qPCR analysis.