Table I. The seven peptides with predicted highest binding affinity to HLA-DR7 efficiently activated PBMC from HLA-DR7+ healthy donors.
ID# | Source | Peptide sequence, ID#, and cell source | Percent PBMC activation relative to Her2 p776 |
---|---|---|---|
43 | Ii− | KVAPAPAVVKKQEAKK | 90% |
45 | Ii− | RTYAGGTASATKVSASSGATSKS | 333%* |
46 | Ii− | SESAAAPAFASSSSEVNPAPKFHW | 83%* |
47 | Ii− | RRMRLTHCGLQEKHL | 52% |
48 | Ii− | GKFYLVIEELSQLFRSLVPIQL | 120% |
42 | Ii− and Ii+ | RQTVAVGVIKAVDKKA | 96% |
44 | Ii− and Ii+ | ELEEALANASDAELCDIAAILGMHTLM | 107% |