Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Aug 23;11(11):1389–1403. doi: 10.1074/mcp.M112.018861

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

Fig. 1. — Detection of endogenous oxidized and nonoxidized forms of the ApoE4-specific peptide LGADMEDVR in plasma from an AD cohort. B, shows extracted ion chromatograms of SRM transitions 511.3/908.4 (blue) and 514.3/914.4 (red) (monitored for mono-oxidized endogenous LGADM(ox)EDVR and heavy LGADM(ox)EDV*R) and transitions 503.3/892.4 (green) and 506.3/898.4 (gray) (monitored for nonoxidized endogenous LGADMEDVR and heavy LGADMEDV*R) in eight plasma samples. The MS/MS spectra correspond to the doubly protonated mono-oxidized endogenous LGADM(ox)EDVR ion (A) and the doubly protonated nonoxidized endogenous LGADMEDVR ion (C). Sixty-eight plasma samples from ε4 allele-bearing subjects (100 μl each) were selected randomly from the AD cohort and digested by trypsin before monitoring SRM transitions 511.3/908.4 and 503.3/892.4 (tracking oxidized and nonoxidized ApoE4-specific peptide LGADMEDVR, respectively) (D).