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Hepatic regulation of lipid and carbohydrate metabolism. Nutritional, hormonal, and pharmacological stimuli modulate AMPK activation, resulting in inhibition of FA and cholesterol synthesis and stimulation of FA oxidation. ACC inhibition lowers malonyl CoA, which in turn inhibits lipid synthesis and activates CPT1. Hepatic activation of AMPK also reduces glucose output. Both ACC and SCD1 are key enzymes in controlling liver lipids.
