TABLE 3.
Quantitative immunostaining of macrophages and oxidation markers by plaque type
| Morphology | Macrophage(KP-1) | ApoB-100(MB47) | MDA-lysine(MDA2) | OxPL (E06) | IK17 | Apo(a)(LPA4) |
| Nonprogressive intimal lesions | ||||||
| AIT (n = 7) | 0.08 ± 0.02 | 0.05 ± 0.03 | 0.4 ± 0.2 | 0.8 ± 0.3 | 0.02 ± 0.02 | 1.5 ± 0.3 |
| IX (n = 8) | 19.4 ± 3.3 | 0.6 ± 0.4 | 0.8 ± 0.30 | 18.1 ± 5.1 | 5.4 ± 4.7 | 11.2 ± 5.9 |
| Early progressive atherosclerotic lesions | ||||||
| PIT (n = 11) | 1.4 ± 0.6 | 3.0 ± 0.9 | 0.9 ± 0.7 | 3.6 ± 0.9 | 2.9 ± 1.5 | 14.3 ± 3.8 |
| EFA (n = 25) | 10.6 ± 1.5 | 1.8 ± 1.1 | 0.5 ± 0.1 | 5.3 ± 1.0 | 8.2 ± 1.6 | 11.8 ± 1.4 |
| Late progressive atherosclerotic lesions | ||||||
| LFA (n = 17) | 11.8 ± 2.1 | 1.3 ± 0.3 | 1.0 ± 0.4 | 7.5 ± 1.9 | 12.9 ± 3.1 | 17.1 ± 3.4 |
| TCFA (n = 13) | 25.5 ± 3.6 | 3.6 ± 1.6 | 1.9 ± 0.6 | 18.0 ± 4.3 | 24.4 ± 4.8 | 31.1 ± 8.4 |
| Plaque rupture (n = 8) | 25.9 ± 6.5 | 2.0 ± 0.7 | 2.3 ± 0.7 | 25.6 ± 5.4 | 31.9 ± 4.9 | 30.1 ± 5.9 |
| P valuea | <0.0001 | 0.45 | 0.50 | <0.0001 | <0.0001 | <0.0001 |
Values represent mean percentage (± SEM) positive stained area of macrophage and lipid oxidation marker within each coronary section classified by dominant lesion type.
a
ANOVA, across all plaque types.