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. Author manuscript; available in PMC: 2012 Nov 9.
Published in final edited form as: Sci Transl Med. 2012 Apr 25;4(131):131ra50. doi: 10.1126/scitranslmed.3003623

Fig. 7.

Fig. 7

Computer simulation of the effects of nilotinib and PI-103 on the canine ventricular action potential. (A) Ratio of ion current densities to control values based on experimental measurements (see Materials and Methods). Data for INa and INaP are from measurements in 10 mM external Na+. Data for ICa,L with PI-103 are from (19). (B) Simulations of the canine ventricular action potential using the modified Hund-Rudy model (see Materials and Methods). Control (black), nilotinib (blue), PI-103 (red), PI-103 effects on IKr and INaP only (dashed red), and ΔIKr (green).